application note

Analyze surface-induced complement activation

- How to characterize immunogenicity with QCM-D

When a biomaterial is introduced into the body, an activation of the complement system resulting in immune response may occur. To prevent such response, it is important to assess the immunogenicity of the biomaterial. In this application note we show how a model system is used to screen and evaluate biomaterial immunogenicity.

In this application note you will find: Analyzing surface induced complement activation

  • Design of model system to analyze surface-induced complement activation
  • Real-time characterization of protein - biomaterial interaction.
  • Evaluation and comparison of five different biomaterial surfaces.  

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