Recorded webinar

Dynamics and Phase behavior of Mixed Antibody Excipient Adsorption at the Air Water Interface

This webinar, part of the Attension Seminar 2021, explores the dynamics and phase behavior of mixed antibody-excipient adsorption at the air-water interface, a critical issue in pharmaceutical formulation. Dr. Ankit D. Kanthe, an Analytical Scientist at Bristol Myers Squibb, presents his research on how monoclonal antibodies and surfactants interact at interfaces, the implications for drug product stability, and strategies to mitigate protein loss during manufacturing and storage

Webinar details

  • Originally aired
    December 08, 2021
  • Length
    23 min
  • Presentation by
    Dr. Ankit D. Kanthe
  • Technologies
    Optical tensiometer
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Protein adsorption to glass and plastics

In this webinar

  • Fundamental mechanisms of antibody and excipient (surfactant) adsorption at the air-water interface in pharmaceutical formulations.

  • Challenges of protein unfolding, irreversible adsorption, and competitive interactions that impact drug product stability.

  • Experimental and analytical techniques used to characterize and mitigate these interfacial phenomena.

Ankit runt

Presentation by Dr. Ankit D. Kanthe

Dr. Ankit D. Kanthe is an Analytical Scientist in the Sterile Drug Product Development group at Bristol Myers Squibb, specializing in interfacial science to understand protein-excipient interactions. With a Ph.D. in chemical engineering from the City University of New York – City College, NY, and chemical engineering from University Institute of Chemical Technology, Mumbai, India, Dr. Kanthe brings deep expertise to the study of antibody behavior at interfaces - a subject central to ensuring the stability and efficacy of modern biopharmaceuticals

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