This overview introduces some of the latest and most cutting-edge uses of QCM-D technology to study biotechnology and biophysics topics, demonstrating the breadth and depth of scientific insights that are possible to obtain with the QCM-D technique. Five case studies are presented to cover different application scenarios and each one provides a broad overview of the study motivation and measurement concepts while offering detailed remarks about experimental operation, data analysis, and future possibilities that will be helpful for novice and advanced users alike.