Stabilization of liquid therapeutic protein formulations with non-ionic surfactants is imperative to avoid critical loss of the active pharmaceutical ingredient by aggregation or adsorption onto different types of interfaces.
In the present work, we have characterized the interfacial activity of different surfactants – alone and in competition with antibodies, by applying a comprehensive suite of experimental techniques including tensiometry, interfacial rheology and quartz-crystal microbalance with dissipation monitoring (QCM-D).
The obtained data show important differences between the surfactants as well as a clear influence of the type of interface considered on the observed behavior. We have linked these physicochemical results to the performance of the surfactants in stabilization of antibodies.
Our findings and the broad spectrum of tests described in this work are instructive towards a better understanding of protein stabilization in distinct primary packaging systems through surfactants in aqueous formulations.
Presenter: Coralie Schneider, PhD
Coralie Schneider is a lab team leader in the Analytical and Material Science department of BASF SE in Ludwigshafen, Germany. Her research interests are surfaces and interfaces with a focus on wetting and adsorption phenomena. Before joining BASF in 2022, she has received a PhD in Theoretical Physics from Heidelberg University.
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