Surface chemistry essentials for QCM-D

This educational presentation offers a clear overview of Quartz Crystal Microbalance with Dissipation (QCMD) technology, focusing on the essential physics and surface chemistry behind adsorption experiments. It begins with the fundamentals of QCMD sensors, explaining quartz crystal vibrations, resonance frequency measurements, and the ring-down method for signal readout. The talk then explores key principles of sensor coatings, including optimal thickness, surface coverage, and how thin-film interference influences sensor appearance. Building on this, the presentation covers surface chemistry concepts such as polarity effects, physisorption versus chemisorption, and how different treatments shape molecular interactions. Real experimental examples illustrate protein and surfactant adsorption, followed by practical guidance on designing robust experiments with the right concentration, flow rate, timing, and contamination control.