Implementing quartz crystal microbalance with dissipation monitoring for the development of novel biosensing assays

Exosomes have shown great importance in intercellular communication and disease transmission. As result, there has been a significant increase in trying novel biosensing platforms that can detect exosomal content such as proteins and nucleic acid with a view toward application in diagnostic assays.

This webinar will present recent efforts on implementing quartz crystal microbalance with dissipation monitoring (QCM-D) for reliable biosensing. The presenter has recently developed an approach, based on QCM-D, for the stepwise functionalization of surface immobilization and subsequent uptake and release of binding partners.

Presenter: Prof. Stefan Guldin

Department of Chemical Engineering, University College London

Dr. Stefan Guldin is a full professor in Chemical Engineering, head of the Adaptive and Responsive Nanomaterials group, and deputy head of the department (Enterprise) at University College London. He studied Physics at Karlsruhe Institute of Technology and the Technical University of Munich and graduated with a PhD from the University of Cambridge in 2012. Subsequently, Dr. Guldin carried out postdoctoral research as a scholar of the German Academy of Sciences at EPFL before taking up his current position in 2015. His research interests include the study of material formation on the nanoscale by molecular self-assembly, creation of adaptive and responsive materials architectures and translation into chemo- & biosensing applications. To date, Dr. Guldin published 58 peer-reviewed articles (incl. Nature Communications, Nano Letters and Advanced Materials) as well as six conference proceedings, one book chapter, and one book. For his work, Dr. Guldin has received awards from the Institute of Physics, the German Academy of Sciences, the German National Academic Foundation, Springer Publishing and the European Materials Research Society. He is co-founder of the biomed start-up Vesynta, which is devoted to the development of companion drug monitoring solutions for personalized medicine with currently 6 full-time employees. His educational platform, which enables to conduct analytical chemistry with a smartphone, is used across 37 countries on 5 continents and received the UCL Education Award 2020. For his teaching related to molecular engineering and nanotechnology, he was recognized in the UCL Student Choice Award (category: “Brilliant Research-Based Education”).

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